The consumption of over-the-counter (OTC) medications during pregnancy is a common concern among expecting mothers. In that context, Tylenol (acetaminophen) is a frequently used analgesic and antipyretic.

The U.S. Food and Drug Administration (FDA) classifies acetaminophen as a Category C drug for pregnant women, which means risk cannot be ruled out. There are several reports that suggest that taking Tylenol when pregnant isn’t the best idea.

In this article, we will hopefully clear up any safety concerns you might have if you are pregnant and need Tylenol.

How Does Tylenol Work, and What Does The FDA Believe?

Acetaminophen, the active ingredient in Tylenol, works by inhibiting an enzyme that produces prostaglandins, which are responsible for causing inflammation and pain.

The exact interaction between acetaminophen and pregnancy physiology still remains unclear. The FDA’s classification of Tylenol indicates that although danger cannot be completely ruled out, the benefits might outweigh the risks in some scenarios.

However, recent studies have prompted some health organizations to seriously reevaluate the safety of acetaminophen during pregnancy. These concerns primarily revolve around the increased potential risk of neurodevelopmental, reproductive, and urogenital disorders in the fetus​.

The controversy finally caused the FDA to release a statement. While they weren’t making any recommendations, they urged pregnant mothers to ‘carefully consider’ Tylenol use.

The Supposed Link To Autism and ADHD

The American College of Obstetricians and Gynecologists acknowledged the growing evidence that prenatal exposure to acetaminophen might have potential risks.

Multiple studies have also shown that acetaminophen may alter fetal development and increase the risk of conditions like ADHD and Autism (ASD)​.

A team of researchers led by Dr. Xiaobing Wang from Johns Hopkins University conducted a study on this subject.  Wang and the team looked at data from nearly a thousand births in the Boston area. In their research, they collected blood from the umbilical cord at birth. This helped them measure how much acetaminophen was in the baby’s system before birth.

It was found that children whose umbilical cord blood had medium or high levels of acetaminophen were more likely to have ADHD or ASD. By the time the children were around 9 years old, about 26% had ADHD, around 7% had ASD, and about 4% had both conditions.

Other studies also showed similar links to ADHD and ASD. A meta-analysis of six European studies found that prenatal acetaminophen exposure increased ADHD and ASD risk by 20%. However, that figure isn’t as serious as it sounds. (If the baseline risk was 4%, a 20% increase would only raise it to about 5%.)

That said, there is clearly some correlation between Tylenol, ADHD, and ASD. TorHoerman Law notes that several mothers are starting to take legal action against its manufacturer Johnson & Johnson and other store-brand manufacturers.

Tylenol autism lawsuit cases can drastically shake up how doctors and families approach pain medication during pregnancy.

What Safe Alternatives Exist?

The current consensus seems to be that the benefits of maternal pain relief through acetaminophen likely outweigh the potential risks to offspring. However, you, as a parent, will need to make that decision.

Remember, there is no reason for you to only choose between Tylenol and pain. There are several alternatives that do not rely on acetaminophen.

Ibuprofen is a popular choice for managing various types of pain. Similarly, aspirin has been a long-standing option for pain relief.

Besides these, many pregnant mothers experience success with more unconventional methods. The American Academy of Family Physicians emphasizes the importance of exploring nonpharmacologic treatments before recommending medication for pregnant mothers.

Some of these alternatives may appear odd, but they have been proven to help. For instance, warm showers, birthing balls, and breathing exercises are commonly used techniques for pain relief.

Hypnosis has also gained attention as a non-pharmacological method for pain relief. Rooted in the power of suggestion and deep relaxation, hypnosis aims to alter perception and sensation, thereby reducing the experience of pain. It is often administered by trained hypnotherapists, although self-hypnosis techniques can also be employed.


It’s imperative for expecting mothers to consult their healthcare providers for personalized advice tailored to their specific needs and conditions. Self-medication, with over-the-counter drugs like Tylenol, should definitely be approached with caution during pregnancy.

As we have seen, the link between prenatal exposure to acetaminophen and conditions like ADHD and ASD is particularly concerning. For the moment, it may be safer to avoid Tylenol during pregnancy or limit your usage of the drug to the minimum.